| Item Type | Name |
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Concept
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Tumor Cells, Cultured
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Concept
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Cells, Cultured
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Academic Article
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Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea.
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Academic Article
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Effect of O6-benzylguanine on the response to 1,3-bis(2-chloroethyl)-1-nitrosourea in the Dunning R3327G model of prostatic cancer.
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Academic Article
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Effects of polyamine analogues on prostatic adenocarcinoma cells in vitro and in vivo.
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Academic Article
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O6-alkylguanine-DNA alkyltransferase inactivation by ester prodrugs of O6-benzylguanine derivatives and their rate of hydrolysis by cellular esterases.
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Academic Article
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Effects of 1,2-naphthoquinones on human tumor cell growth and lack of cross-resistance with other anticancer agents.
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Academic Article
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Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.
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Academic Article
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In vitro and in vivo activity of protein kinase C inhibitor chelerythrine chloride induces tumor cell toxicity and growth delay in vivo.
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Academic Article
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Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
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Academic Article
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Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
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Academic Article
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Effect of cell cycle inhibition on Cisplatin-induced cytotoxicity.
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Academic Article
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Role of glutathione and nucleotide excision repair in modulation of cisplatin activity with O6-benzylguanine.
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Academic Article
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Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.
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Academic Article
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Modulation of mammalian O6-alkylguanine-DNA alkyltransferase in vivo by O6-benzylguanine and its effect on the sensitivity of a human glioma tumor to 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea.
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Academic Article
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Pharmacogenomic discovery using cell-based models.
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Academic Article
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Human liver oxidative metabolism of O6-benzylguanine.
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Academic Article
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Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells.
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Academic Article
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Effect of 1,19-bis(ethylamino)-5,10,15-triazanonadecane on human tumor xenografts.
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Academic Article
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Structural features of substituted purine derivatives compatible with depletion of human O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Use of antibodies to human O6-alkylguanine-DNA alkyltransferase to study the content of this protein in cells treated with O6-benzylguanine or N-methyl-N'-nitro-N-nitrosoguanidine.
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Academic Article
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Intracellular activation of cytotoxic agents: kinetic models for methylnitrosoureas and N-methyl-N'-nitro-N-nitrosoguanidine in cell culture.
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Academic Article
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Investigation of the specificity of O6-alkylguanine-DNA-alkyltransferase.
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Academic Article
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Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate.
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Academic Article
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Production of antibodies to peptide sequences present in human O6-alkylguanine-DNA alkyltransferase and their use to detect this protein in cell extracts.
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Academic Article
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Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.
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Academic Article
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Repair of O-alkylpyrimidines in mammalian cells: a present consensus.
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Academic Article
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Increased killing of prostate, breast, colon, and lung tumor cells by the combination of inactivators of O6-alkylguanine-DNA alkyltransferase and N,N'-bis(2-chloroethyl)-N-nitrosourea.
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Academic Article
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The effects of O6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea in nitrosourea-resistant SF-763 cells.
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Academic Article
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Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
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Academic Article
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8-Substituted O6-benzylguanine, substituted 6(4)-(benzyloxy)pyrimidine, and related derivatives as inactivators of human O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Substituted O6-benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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O6-benzylguanine potentiates the antitumor effect of locally delivered carmustine against an intracranial rat glioma.
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Academic Article
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The role of O6-alkylguanine-DNA alkyltransferase in protecting Rat4 cells against the mutagenic effects of O6-substituted guanine residues incorporated in codon 12 of the H-ras gene.
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Academic Article
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Modulation of cyclophosphamide activity by O6-alkylguanine-DNA alkyltransferase.
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Academic Article
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Schedule-dependent activity of temozolomide plus CPT-11 against a human central nervous system tumor-derived xenograft.
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Academic Article
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Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
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Academic Article
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Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
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Academic Article
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Poly(ADP-ribose) polymerase-1 inhibition reverses temozolomide resistance in a DNA mismatch repair-deficient malignant glioma xenograft.
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Academic Article
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Evaluation of inter-batch differences in stem-cell derived neurons.
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Academic Article
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Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.
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